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Patriots vs. Bills odds, line, spread: Monday Night Football picks, predictions from model on 118-76 roll - CBS Sports

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The Buffalo Bills will look to solidify the No. 2 seed in the AFC playoff picture when they visit the New England Patriots on Monday Night Football. The Bills (11-3) have been red-hot, winning four straight, and are coming off a 48-19 win over the Denver Broncos. The Patriots (6-8) have lost two in a row and had their streak of 11 consecutive postseason appearances come to an end. Buffalo is 4-0 this season against AFC East opponents. 

Kickoff from Gillette Stadium is set for 8:15 p.m. ET. The Bills are seven-point favorites in the latest Patriots vs. Bills odds from William Hill Sportsbook, while the over-under is 46. Before making any Bills vs. Patriots picks, check out the NFL predictions from the SportsLine Projection Model

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception five-plus years ago. It is a sizzling 22-11 on top-rated NFL picks this season, returning over $800. The model also enters Week 16 on an incredible 118-76 run on top-rated NFL picks that dates back to the 2017 season. 

The model ranked in the Top 10 on NFLPickWatch three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up. 

Now, the model has set its sights on Patriots vs. Bills. You can visit SportsLine now to see the picks. Here are the NFL lines and trends for Bills vs. Patriots:

  • Patriots vs. Bills spread: Bills -7
  • Patriots vs. Bills over-under: 46 points
  • Patriots vs. Bills money line: Bills -320, Patriots +260
  • BUF: Over has hit in nine Bills games this season
  • NE: 4-0 all-time against Buffalo on Monday Night Football 

Why the Bills can cover

Buffalo has posted its first 11-win season since 1999, and a major reason for that is the play of quarterback Josh Allen. In 14 games, Allen has completed 351 of 511 passes for 4,000 yards and 30 touchdowns. He has been intercepted just nine times and has a rating of 104.2. He has also rushed 96 times for 383 yards and eight touchdowns.

Also powering the offense is running back Devin Singletary. He had 84 yards from scrimmage, including 68 rushing and a TD against Denver last week. Singletary has registered 80 or more yards from scrimmage in three of the past four games. In the Week 8 meeting against the Patriots, he rushed for a season-high 86 yards.

Why the Patriots can cover

Despite that, Buffalo is not a lock to cover the Bills vs. Patriots spread. That's because New England has been in nearly every game this season and has four losses by seven points or fewer. Quarterback Cam Newton completed 17 of 27 passes for 209 yards and rushed for 38 yards last week at Miami. He passed for 174 yards and rushed for 54 yards and a touchdown in the Week 8 matchup against the Bills and has a 95 or better rating in three of his past four games on Monday Night Football. 

Running back Sony Michel has 100 or more yards from scrimmage in two of three career games against the Bills. He has also rushed for a touchdown in two of his past three home games. In his only career game on Monday Night Football, he had a career-high three rushing touchdowns against the New York Jets on Oct. 21, 2019. Last week at Miami, Michel rushed for 74 yards.

How to make Bills vs. Patriots picks

SportsLine's model is leaning over on the total. In fact, it says Allen will throw for nearly 300 yards and two touchdowns, while New England quarterback Cam Newton will have more than 200 yards from scrimmage and two TDs. It also says one side of the spread has all the value. You can only get the pick here

So who wins Bills vs. Patriots on Monday Night Football? And which side of the spread has all the value? Visit SportsLine now to see which side of the Bills vs. Patriots spread to jump on, all from the advanced model that is up well over $7,900 on its NFL picks over the past five seasons, and find out.

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Patriots vs. Bills odds, line, spread: Monday Night Football picks, predictions from model on 118-76 roll - CBS Sports
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