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College football odds, picks, predictions for Week 11, 2020: Model backing Ohio State, Mississippi State - CBS Sports

NCAA Football: Texas A&M at Alabama
Gary Cosby Jr / USA TODAY Sports

Notre Dame made a huge statement on Saturday, knocking off previously top-ranked Clemson to put itself squarely in the College Football Playoff picture. The Irish, now up to No. 2 in the AP Poll, will look to keep the momentum rolling as they travel to take on Boston College at 3:30 p.m. ET in an important matchup on the Week 11 college football schedule. The latest Week 11 odds from William Hill Sportsbook list the Irish as 13-point favorites.

Is that one of the games you should target in your Week 11 college football bets? And which college football spreads around the nation have value as at least one FBS matchup unfolds every day starting Tuesday? Before locking in any Week 11 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of almost $3,900 for $100 players on its top-rated college football picks against the spread. It is a sizzling 37-20 on all top-rated picks through 10 weeks of the 2020 college football season, returning over $900 in profit already. Anybody who has followed it is way up. 

Now, it has turned its attention to the latest college football odds for Week 11 from William Hill and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 11 college football predictions 

One of the top Week 11 college football picks the model is recommending: No. 3 Ohio State (-25.5 at William Hill) covers on the road against Maryland in a 3:30 p.m. ET matchup on Saturday. The Buckeyes are 3-0 overall and have already covered two double-digit lines this season. Maryland has bounced back nicely from an embarrassing 43-3 loss to Northwestern to open the season as the Terrapins have upset Minnesota and Penn State in consecutive weeks.

But SportsLine's model doesn't see Taulia Tagovailoa and the Terrapins keeping it close against the loaded Buckeyes. The model expects Justin Fields to throw for well over 300 yards and almost four touchdowns as the Buckeyes cover in more than 60 percent of simulations. The under (72.5) also has plenty of value since the simulations are calling for just 62 total points in this matchup. 

Another one of the top Week 11 college football predictions from the model: No. 10 Indiana (-7.5) covers on the road against Michigan State in a Big Ten battle at noon ET on Saturday. The Hoosiers have been one of college football's biggest surprises thus far in 2020. After upsetting Michigan last week, they're off to a 3-0 start and have covered in all three game.

Michigan State, meanwhile, has been inconsistent. The Spartans did pick up a big rivalry upset over Michigan in their second game. But that win is sandwiched by double-digit losses against Rutgers and Iowa. The model is calling for almost 250 yards and two touchdowns through the air for Indiana quarterback Michael Penix Jr. as the Hoosiers cover in well over 50 percent of simulations. 

How to make Week 11 college football picks 

The model has also made the call on who wins and covers in every other Week 11 FBS matchup, and it is also predicting a major upset in the Big 12. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence in Week 11? And which Big 12 underdog will pull off a shocking upset? Check out the latest Week 11 college football odds for some of the week's most notable games below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,900 in profit over the past four-plus seasons, and find out.

Week 11 college football odds (via William Hill)

Tuesday, Nov. 10

Akron at Ohio (-26.5)

Latest Odds: Bobcats -27.5

Kent State at Bowling Green (+19)

Latest Odds: Golden Flashes -20.5

Miami (OH) at Buffalo (-9.5)

Latest Odds: RedHawks +9.5

Wednesday, Nov. 11

Eastern Michigan at Ball State (+10.5)

Latest Odds: Eagles +8.5

Central Michigan at Northern Illinois (+7)

Latest Odds: Chippewas -7.5

Toledo at Western Michigan (+1)

Latest Odds: Broncos -2.5

Thursday, Nov. 12

Colorado State at Boise State (-13)

Latest Odds: Broncos -13

Friday, Nov. 13 

Iowa at Minnesota (+2.5)

Latest Odds: Golden Gophers +3.5

East Carolina at Cincinnati (-27)

Latest Odds: Bearcats -27.5

Florida Atlantic at Florida International (+8.5)

Latest Odds: Panthers +8.5

Saturday, Nov. 14

Miami (FL) at Virginia Tech (-2.5)

Latest Odds: Hurricanes +2.5

Penn State at Nebraska (+3)

Latest Odds: Cornhuskers +3

Notre Dame at Boston College (+13)

Latest Odds: Fighting Irish -13.5

Ohio State at Maryland (+25.5)

Latest Odds: Buckeyes -24.5

USC at Arizona (+13.5)

Latest Odds: Trojans -14

Baylor at Texas Tech (-1.5)

Latest Odds: Bears +1.5

Texas A&M at Tennessee (+8)

Alabama at LSU (+24)

Arkansas at Florida (-16.5)

Latest Odds: Gators -17.5

Oregon at Washington State (+7.5)

Latest Odds: Ducks -8.5

Oregon State at Washington (-12.5)

Latest Odds: Huskies -13

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