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College football odds, lines, predictions for Championship Week, 2021: Model backs Oklahoma State, Cincinnati - CBSSports.com

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No. 2 Michigan has jumped into one of the College Football Playoff spots following its win over Ohio State last week. The Wolverines will face No. 13 Iowa in the Big Ten Championship Game during part of the Championship Week college football schedule this weekend. They are 10.5-point favorites in the latest Championship Week college football odds at Caesars Sportsbook. Another game with direct playoff implications will take place when No. 1 Georgia faces No. 3 Alabama in the the SEC Championship Game (4 p.m. ET, CBS) on Saturday.

The Bulldogs are 6.5-point favorites in their game in Atlanta against the Crimson Tide. Should you be backing Georgia and its stout defense, or can Alabama book its spot in the playoff? And which other college football lines should you be targeting? Before making any college football picks for Championship Week, be sure to see the latest college football predictions and betting advice from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Championship Week 2021 on a 42-28 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Championship Week college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Championship Week

One of the top college football picks the model is recommending for Championship Week: No. 4 Cincinnati (-10.5) covers against No. 21 Houston in the AAC Championship Game at 4 p.m. ET on Saturday. The Bearcats are in a position to make the College Football Playoff with a win in this game. They went undefeated in the regular season, winning their 12 games by an average of 15.9 points. Their defense finished third in the country, allowing just 15.8 points per game.

Houston quarterback Clayton Tune threw four interceptions in a season-opening loss to Texas Tech and this will be an even tougher task. SportsLine's model projects Tune to throw at least one interception on Saturday afternoon. The model has Cincinnati covering the spread in 60 percent of simulations, while the over (53) is hitting well over 50 percent of the time. 

Another one of the college football predictions from the model: No. 5 Oklahoma State (-5), fresh off a massive Bedlam win over rival Oklahoma, continues its roll and knocks off the No. 9 Baylor Bears in the Big 12 Championship Game at noon ET on Saturday. This is a rematch of an Oct. 2 matchup that Oklahoma State won 24-14, covering a four-point spread in that matchup. SportsLine's model is calling for a similar outcome in this matchup in Arlington, Texas.

Oklahoma State's stout defense holds Baylor to just 18 points in the simulations. The Cowboys score 27, giving them a nine-point victory. That helps them cover the spread well over 50 percent of the time. The under (46.5), meanwhile, hits in almost 60 percent of simulations. 

How to make Championship Week college football picks 

The model has also made the call on who wins and covers in every other game during the Championship Week college football schedule, and it's projecting multiple underdogs to win outright. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which underdogs do you need to jump on now? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,700 in profit over the past five-plus seasons, and find out.

Championship Week college football odds (via Caesars)

Here are the college football lines for Championship Week:

Friday, Dec. 3

Conference USA: Western Kentucky vs. UTSA (+1.5, 72)

Featured Game | UTSA Roadrunners vs. Western Kentucky Hilltoppers

Pac-12: Oregon vs. Utah (-2.5, 60)

Featured Game | Utah Utes vs. Oregon Ducks

Saturday, Dec. 4

MAC: Kent State vs. Northern Illinois (+3, 72.5)

Featured Game | Northern Illinois Huskies vs. Kent State Golden Flashes

Big 12: Baylor vs. Oklahoma State (-5, 46.5)

Featured Game | Oklahoma State Cowboys vs. Baylor Bears

Mountain West: Utah State vs. San Diego State (-6, 50.5)

Featured Game | San Diego State Aztecs vs. Utah State Aggies

Sun Belt: Appalachian State vs. Louisiana (+3, 52.5)

Featured Game | Louisiana Ragin' Cajuns vs. Appalachian State Mountaineers

SEC: Georgia vs. Alabama (+6.5, 50)

Featured Game | Alabama Crimson Tide vs. Georgia Bulldogs

AAC: Houston vs. Cincinnati (-10.5, 54)

Featured Game | Cincinnati Bearcats vs. Houston Cougars

ACC: Pittsburgh vs. Wake Forest (+3, 72.5)

Featured Game | Wake Forest Demon Deacons vs. Pittsburgh Panthers

Big Ten: Michigan vs. Iowa (+10.5, 43.5)

Featured Game | Iowa Hawkeyes vs. Michigan Wolverines

USC vs. California (-2.5, 57.5)

Featured Game | California Golden Bears vs. USC Trojans

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